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Methotrexate (Non-Cancer)

Drug Class: Commonly Known As: Category:
Immune Suppressant Adult

Methotrexate (Non-Cancer) - What is it for

Methotrexate belongs to a class of medicines called disease modifying anti-rheumatic drugs (DMARDs). DMARDs reduce symptoms such as pain and swelling and slow down the progress of certain autoimmune diseases (disease where the body's natural defence system attacks own body cells) such as:


Psoriatic arthritis

Rheumatoid arthritis

Systemic lupus erythematosus


Inflammatory bowel disease

In the long term, it reduces permanent damage to the organs such as joints, lung and skin. It may be used on its own or in combination with other DMARDs or biologic agents.


  • Methotrexate is also used in non-autoimmune diseases. It is not within the scope of this material to cover information for such conditions.
  • This material provides information for people being treated with low dose Methotrexate (25 milligrams or less per week).
  • Updated on 10/24/2017 12:00:00 AM
  • Article contributed by Pharmacy Department, Rheumatology & Immunology KK Women's and Children's Hospital, Singapore General Hospital
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

This leaflet answers some common questions about Methotrexate. It does not contain all the available information. It also does not take the place of talking to your doctor or pharmacist.

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