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Leflunomide - Additional Information

    Do I skip dose if I am SICK?

  • Seek prompt advice from your doctor when you develop any of the serious symptoms of infection.
  • Your doctor will decide whether to stop leflunomide on a case-by-case basis.


  • This medication can cause serious birth defects, and this risk may persist long after the drug is discontinued.
  • Women of childbearing potential should not receive therapy until pregnancy has been excluded and they have been counseled concerning fetal risk. Use of an effective form of birth control is critical throughout the course of this treatment and for up to two years after it is stopped. This is important, because leflunomide lasts in the body a long time, even after stopping the medication, and could still cause birth defects during this time.
  • It is not known if males taking leflunomide may contribute to fetal toxicity. Men should use effective contraception for 3 months after stopping leflunomide.
  • Both men and women who are on the medication and want to have a child should ask their doctors to prescribe another drug—cholestyramine—to help remove leflunomide from their systems.
  • For mothers receiving leflunomide, breastfeeding is not recommended.

    In SUMMARY… what you need to know about Leflunomide:

  • Take leflunomide once daily, approximately the same time each day.
  • Always come for your BLOOD TESTS on the scheduled date.
  • Beware of the SIDE EFFECTS and when to get immediate medical attention.
  • Never take medicines, supplements or herbal treatments OVER-THE-COUNTER without checking with your doctor or pharmacist first.
  • For female patient intents to start a family, please inform your doctor.
  • If you have further questions about Leflunomide, please call ______________________ (office number) to discuss with your doctor / pharmacist / specialty nurse (please circle as
  • Updated on 6/12/2015 12:00:00 AM
  • Article contributed by Pharmacy, Rheumatology & Immunology Singapore General Hospital
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth


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