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Cyclophosphamide (Non-Cancer)

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Cyclophosphamide (Non-Cancer) - Dosage and How to Use

How should Cyclophosphamide (Non-Cancer) be used?

  • It may be given as
    • Intravenous infusion (inject into the blood vessel). This has to be done in the hospital for typically a few hours.
    • By mouth
      • Take the tablets with or after food to reduce stomach upset. It can cause nausea and vomiting at the start of therapy, but if the dose is increased slowly, your body will usually get used to it.
      • Do not take the tablets at bedtime when the urine concentrates overnight to minimize the risk of irritation to the bladder.
      • The tablets should be swallowed whole, with a glass of water. The tablets should not be crushed or chewed.
  • Dosage and duration of cyclophosphamide will depend on your body weight, disease activity and response to the medication. 
  • This medication does not work immediately. It may take between 6 to 12 weeks before you notice any benefit. Thus, it is important that you take your medication or come back for infusion regularly, otherwise you may not benefit at all.
  • Do not stop taking your medication without checking with your healthcare professional.
  • Other medications such as corticosteroids (e.g. prednisolone) or disease modifying anti-rheumatic drugs (DMARDs) may be taken with cyclophosphamide.

What should I do if I miss a dose?

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dose. Do not take double doses to make up for the missed dose.

If you miss your infusion appointment, book another appointment as soon as possible. Inform your doctor about the missed/ late dose.

What should I do if I overdose?

  • Updated on 12/31/2022 12:00:00 AM
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

This leaflet answers some common questions about Cyclophosphamide. It does not contain all the available information. It also does not take the place of talking to your doctor or pharmacist.

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