Skip Ribbon Commands
Skip to main content
Menu

Cabozantinib

Drug Class: Commonly Known As: Category:
Multi-Kinase Inhibitor Cometriq, Cabometyx Adult, Cancer-related

Cabozantinib - Side Effects, Precautions, and Contraindications

What side effects can Cabozantinib cause?

  • ​Nausea, decreased appetite
    • Take small, frequent meals throughout the day
  • Diarrhea
    • Drink plenty of clear fluids to replace those lost (two litres everyday)
  • Palms of the hands or soles of the feet may become numb, sore, red or dry
    • Moisturize these areas daily
    • Avoid wearing tight-fitting shoes
  • Feeling tired and lack of energy
    • Do not drive or operate machinery when you feel tired
  • Mouth sores
    • Rinse your mouth after meals using an alcohol-free mouthwash or salt water
    • Brush your teeth with a soft toothbrush
  • Increased blood pressure
    • Monitor your blood pressure regularly and record it down. Inform your doctor if you notice an increasing trend.
If you experience any of the following symptoms, you should stop your medication and see your healthcare professional immediately. 
  • Very bad stomach pain
  • Signs of infection - fever of 38° C and above, chills, cough, sore throat, pain or burning feeling on passing urine
  • Unusual bleeding, bruising, black sticky stools or blood in the urine
  • Unusual weakness, tiredness or light-headedness
  • Signs of blood clot e.g. warmth, pain or redness with swelling on arm or leg
  • Chest pain or shortness of breath
  • Very bad diarrhea
  • Painful blisters and peeling of hands or feet
  • Symptoms of a drug allergy including one or more of the following:
    • Swollen face/eyes/lips/tongue
    • Difficulty in breathing
    • Itchy skin rashes over your whole body

    Before taking Cabozantinib, what precautions must I follow?

    ​Inform your healthcare professional if:

    • You are allergic to this medication
    • You or your partner becomes pregnant or is planning for pregnancy
      • You should use effective birth control during and for four months after stopping treatment
    • You are breastfeeding
      • Do not breastfeed during and for four months after stopping treatment
    • You have any other medical conditions such as heart problems or high blood pressure
    • You are taking or intend to take any other medications, including supplements, traditional medications and herbal remedies
    • You have any recent or upcoming surgery
    • You have any dental problems
      • Practice good oral hygiene while you are taking Cabozantinib
      • Be sure to let your dentist know you are taking Cabozantinib so that appropriate precautions can be taken

    What food or medicine must I avoid when I take Cabozantinib?

    ​Avoid taking grapefruit or grapefruit juice when you are taking this medication as it may interact with your medication and increase the risk of side-effects.

    Cabozantinib - Additional Information

    • Updated on Monday, August 31, 2020
    • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup

      The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

      ​If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

      Find Your Medicines