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Prof Teh Bin Tean

Prof Teh Bin Tean

B. Med. Sc. (1st class Honors), M.B.B.S. (Medicine), Ph.D. (Medical Genetics)

National Cancer Centre Singapore

Academic Appointments

  • Director, SingHealth Duke-NUS Institute of Biodiversity Medicine (BD-MED)
  • Deputy Medical Director (Research)
  • Deputy Director (Global Relations)
  • Professor, Duke-NUS Medical School, Singapore
  • Senior Principal Investigator, Institute of Molecular and Cell Biology, Singapore
  • Senior Group Leader, Genome Institute of Singapore

Profile

Professor Teh obtained his MD (1992) from the University of Queensland, Australia and his PhD (1997) from the Karolinska Institute, Sweden. He is currently the Deputy Director (Research) of the National Cancer Centre of Singapore, and Director of SingHealth Duke-NUS Institute of Biodiversity Medicine (BD-MED).

He is a past and present member of the editorial boards / editor of Lancet Oncology, Cancer Research, Molecular Cancer Therapeutics, International Journal of Cancer and Science Translational Medicine. His laboratory has been focusing on Genomics and Epigenomics of Asian-Prevalent Cancers such as hepatobiliary cancer, herbal carcinogen-related cancer and breast fibroepithelial tumors.  Dr Teh is a recipient of the 2015 Singapore President Science Award, 2018 AACR Team Science Award, and plenary lecturer at the 2019 AACR Annual Meeting.

Education

  • ​Ph.D. (Medical Genetics) Karolinska Institute, Sweden (1997)
  • M.B.B.S. (Medicine)  University of Queensland, Australia (1992)
  • B. Med. Sc. (1st class Honors) University of Tasmania, Australia (1989)

Professional Appointments and Committee Memberships

  • Visiting Professor, Kumamoto University, Japan (04/2019 – 03/2021)

  • Chair Professor, China Medical University, Taiwan (02/2018 – present)

  • Adjunct Professor, Baylor College of Medicine, USA (07/2005 – present)
  • Adjunct Professor, Karolinska Institute, Sweden (01/2003 – present)
  • Editorial Board Member, Science Translational Medicine (01/2020 – present)
  • Editorial Board Member, International Journal of Cancer (01/2020 – present)

Awards

  • 2019 – 2024 Singapore Translational Research Investigator Award
  • 2018 AACR Team Science Award
  • 2015 President’s Science Award
  • 2015 SingHealth Excellence Awards – Distinguised Researcher Award
  • 2015 – 2020 Singapore Translational Research Investigator Award
  • 2014 American Society for Clinical Investigation (ASCI)
  • 2013 Honorable Member, Romanian Academy of Medical Sciences
  • 2008 University of Queensland International Alumnus of the Year Highly Commended Nominee, Australia

Research Interests

  • Translational Cancer Research (urological cancer, hepatobiliary cancer, breast fibroepithelial tumors)
  • Health-related plant biodiversity

Publications

​Selected Publications (out of 416)

  • Jusakul A, Cutcutache I, Yong CH, Lim JQ, Huang MN, Padmanabhan N, Nellore V, Kongpetch S, Ng AWT, Ng LM, Choo SP, Myint SS, Thanan R, Nagarajan S, Lim WK, Ng CCY, Boot A, Liu M, Ong CK, Rajasegaran V, Lie S, Lim AST, Lim TH, Tan J, Loh JL, McPherson JR, Khuntikeo N, Bhudhisawasdi V, Yongvanit P, Wongkham S, Totoki Y, Nakamura H, Arai Y, Yamasaki S, Chow PK, Chung AYF, Ooi LLPJ, Lim KH, Dima S, Duda DG, Popescu I, Broet P, Hsieh SY, Yu MC, Scarpa A, Lai J, Luo DX, Carvalho AL, Vettore AL, Rhee H, Park YN, Alexandrov LB, Gordân R, Rozen SG, Shibata T, Pairojkul C, Teh BT, Tan P. Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma. Cancer Discov 7(10): 1116-1135, 2017
  • Teh BT, Lim K, Yong CH, Ng CCY, Rao SR, Rajasegaran V, Lim WK, Ong CK, Chan K, Cheng VKY, Soh PS, Swarup S, Rozen SG, Nagarajan N, Tan P. The draft genome of tropical fruit durian (Durio zibethinus). Nat Genet 49(11): 1633-1641, 2017
  • Tan J, Ong CK, Lim WK, Ng CCY, Thike AA, Rajasegaran V, Myint SS, Nagarajan S, Thangaraju S, Dey S, Ng, LM, Nasir ND, Wijaya GC, Huang D, Wong BH, Chan JYS, McPherson JR, Cutcutache I, Poore G, Tay ST, Tan WJ, Putti TC, Buhari SA, Iau P, Chan CW, Tang APT, Yong WS, Madhukumar P, Ho GH, Tan VKM, Wong, CY, Hartman M, Ong KW, Tan BKT, Rozen SG, Tan P, Tan PH, Teh BT. Genomic progression of breast fibroepithelial tumors. Nature Genet 47(11): 1341-5, 2015
  • Lim WK, Ong CK, Tan J, Thike AA, Ng CC, Rajasegaran V, Myint SS, Nagarajan S, Nasir ND, McPherson JR, Cutcutache I, Poore G, Tay ST, Ooi WS, Tan VK, Hartman M, Ong KW, Tan BK, Rozen SG, Tan PH, Tan P, Teh BT. Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. Nat Genet 46(8): 877–880, 2014
  • Chan-on W, Nairismägi M-L, Ong CK, Dima S, Pairojkul C, Lim KH, McPherson JR, Lim WK, Cucutache I, Heng HL, Ooi L, Chung A, Chow P, Cheow PC, Lee SY, Huat ITB, Duda D, Nastase A, Myint SS, Wong BH, Gan A, Rajasegaran V, Ng CCY, Jusakul A, Zhang S, Vohra P, Yu W, Huang D, Yongvanit P, Wongkham S, Khuntikeo N, Bhudhisawasdi V, Popescu I, Rozen SG, Tan P, Teh BT. Distinct mutational patterns of infection and non-infection-related bile duct cancers revealed by exome sequencing. Nat Genet 45(12): 1474-1478, 2013
  • Poon SL, Pang ST, McPherson JR, Yu W, Huang KK, Guan P, Weng WH, Siew EY, Liu Y, Heng HL, Chong SC, Gan A, Tay ST, Lim WK, Cutcutache I, Huang D, Ler LD, Nairismägi ML, Lee MH, Chang YH, Yu KJ, Chan-On W, Li BK, Yuan YF, Qian CN, Ng KF, Wu CF, Hsu CL, Bunte RM, Stratton MR, Futreal PA, Sung WK, Chuang CK, Ong CK, Rozen SG, Tan P, Teh BT. Genome-wide mutational signatures of aristolochic acid and its application as a screening tool. Sci Transl Med 5(197): 197ra101, 2013
  • Ong CK, Subimerb C, Pairojkul C, Wongkham S, Cutcutache I, Yu W, McPherson JR, Allen GE, Ng CC, Wong BH, Myint SS, Rajasegaran V, Heng HL, Gan A, Zang ZJ, Wu Y, Wu J, Lee MH, Huang D, Ong P, Chan-on W, Cao Y, Qian CN, Lim KH, Ooi A, Dykema K, Furge K, Kukongviriyapan V, Sripa B, Wongkham C, Yongvanit P, Futreal PA, Bhudhisawasdi V, Rozen S, Tan P, Teh BT. Exome sequencing of liver fluke-associated cholangiocarcinoma. Nat Genet 44(6): 690-3, 2012

Research Trials

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