Prof Salvatore Albani

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Prof Albani Salvatore

Profile

Professor Salvatore Albani is an internationally renowned rheumatologist and immunologist. He is a Professor at Duke-NUS Medical School and Director of the Translational Immunology Institute at SingHealth- Duke-NUS Medical Centre. Before joining Duke-NUS, Professor Albani served as director of the Translational Medicine Unit at the Clinical Investigation Institute at the University of California, San Diego, where he also was professor of Medicine and Pediatrics. His fundamental research interest is in understanding human immunity and contributing the knowledge to therapeutic and diagnostic advancements. He has developed several innovative approaches in the area of induction and maintenance of immune tolerance in humans, being responsible for the whole translational process from idea to the conclusion of a Phase II clinical trial in autoimmune inflammatory diseases, which have a large impact on society and individuals.

He has been responsible for conception and execution of each of the stages of this complex itinerary, which spans a wide and diverse gradient of technologies and challenges. These include molecular immunology, lead identification and validation, intellectual property, CMC (Chemistry, Manufacturing and Controls), IND (Investigational New Drug filings), trial design, data management and analysis, interfacing with Venture Capital and Pharma, leading complex groups in a multi-center setting, etc. The technology platform has applications in diseases that could benefit from a restoration of immune tolerance. This translational research itinerary has been the original backbone of his career, as witnessed by a rich publication trail (among others Nature Medicine, Lancet, JCI, PNAS, Nature Rheumatology, A&R, ARD, etc, H factor 34) and by approximately 100 patents. Development of high throughput technology platforms is also part of his scientific career. These platforms aim to provide tools for knowledge-based diagnostic and therapeutic decisions.

In his role as an educator, it has been his privilege to mentor many talented individuals, and to provide the right challenges and learning opportunities to help them grow and advance. He seeks to expand this even further by helping to create and nurture the next generation of translational scientists.

Education

Doctor of Medicine, University of Pavia, Italy

Professional Appointments and Committee Memberships

Co-founder and President of the Eureka Institute for Translational Medicine, an international organisation focused on the advancement of Translational Medicine through research, education and policy shaping
Director, Translational Immunology Institute (TII)

Awards

SingHealth Excellence Distinguished Researcher Award - SingHealth, 2019
Singapore Translational Research (STaR) Investigator Award - NMRC, 2013
Nature Biotechnology, Outstanding Research Achievement Award - 2012

Research Interests

Understanding human immunity and contributing the knowledge to therapeutic and diagnostic advancements

Publications

Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis. Widjaja Anissa A, Singh Brijesh K, Adami Eleonora, Viswanathan Sivakumar, Dong Jinrui, D'Agostino Giuseppe A, Ng Benjamin, Lim Wei Wen, Tan Jessie, Paleja Bhairav S, Tripathi Madhulika, Lim Sze Yun, Shekeran Shamini Guna, Chothani Sonia P, Rabes Anne, Sombetzki Martina, Bruinstroop Eveline, Min Lio Pei, Sinha Rohit A, Yen Paul M, Schafer Sebastian, Cook Stuart A and Salvatore Albani. Gastroenterology 157 (3); 777-792.e14;(2019). 09 May 2020.

https://linkinghub.elsevier.com/retrieve/pii/S0016508519408585

The Extended Polydimensional Immunome Characterization (EPIC) web-based reference and discovery tool for cytometry data. Joo Guan Yeo , Martin Wasser , Pavanish Kumar, Lu Pan , Su Li Poh, Fauziah Ally, Thaschawee Arkachaisri , Amanda Jin Mei Lim, Jing Yao Leong , Liyun Lai, Kee Thai Yeo , elene Seck Choon Lee, Camillus Jian Hui Chua, Anis Larbi, Ma Shwe Zin Nyunt, Tze Pin Ng, Sabrina Chiesa, Marco Gattorno, Alberto Martini, Bhairav Suryakant Paleja, Charles-Antoine Dutertre, Jinmiao Chen , Katherine Nay Yaung, Swee Ping Tang, Sue Kheng Ng, Chee Fu Yung, Angela Yun June Tan, Shu Ying Lee, Florent Ginhoux and Salvatore Albani. Nat Biotechnology 38, 679–684 (2020). 21 May 2020. https://www.nature.com/articles/s41587-020-0532-1

Immunome perturbation is present in juvenile idiopathic arthritis patients who are in remission and will relapse upon anti-TNFα withdrawal. Jing Yao Leong, Phyllis Chen, Joo Guan Yeo, Fauziah Ally, Camillus Chua, Sharifah Nur Hazirah, Su Li Poh, Lu Pan, Liyun Lai, Elene Seck Choon Lee, Loshinidevi D/o Thana Bathi, Thaschawee Arkachaisri, Daniel Lovell, Salvatore Albani,. Annals of Rheumatic Diseases (ARD). 2019;78:1712-1721. https://ard.bmj.com/content/78/12/1712

Insights into the immuno-pathogenesis of acute respiratory distress syndrome. Judith Ju Ming Wong, Jing Yao Leong, Jan Hau Lee, Salvatore Albani, Joo Guan Yeo. Ann Transl Med 2019;7(19):504.

http://atm.amegroups.com/article/view/29655/25958

Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells. Charles-Antoine Dutertre, Etienne Becht, Sergio Erdal Irac, Ahad Khalilnezhad, Vipin Narang, Shabnam Khalilnezhad, Pei Y. Ng, Lucas L. van den Hoogen, Jing Yao Leong, Bernett Lee, Marion Chevrier, Xiao Meng Zhang, Pearly Jean Ai Yong, Geraldine Koh, Josephine Lum, Shanshan Wu Howland, Esther Mok, Jinmiao Chen, Anis Larbi, Henry Kun Kiaang Tan, Tony Kiat Hon Lim, Panagiota Karagianni, Athanasios G. Tzioufas, Benoit Malleret, Joshua Brody, Salvatore Albani, Joel van Roon, Timothy Radstake, Evan W. Newell, Florent Ginhoux. Immunity. P573-589.E8. 17 September 2019.

https://www.cell.com/immunity/fulltext/S1074-7613(19)30334-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761319303346%3Fshowall%3Dtrue