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Prof Hausenloy Derek

Prof Derek Hausenloy from National Heart Centre Singapore

Prof Hausenloy Derek

​PhD, MBChB (Honours), BSc

Senior Consultant

National Heart Centre Singapore

Specialty: Cardiology

Sub-specialties: Cardiac Magnetic Resonance Imaging

Clinical Appointments

  • Senior Consultant Department of Cardiology National Heart Centre SingaporeNational Heart Centre Singapore

Profile

Professor Derek Hausenloy is a Professor in the Cardiovascular & Metabolic Disorders Signature Programme, Duke-National University of Singapore Medical School, and Senior Consultant from the Department of Cardiology at the National Heart Centre Singapore (NHCS). He is also a Clinician Scientist and a Professor in the Institute of Cardiovascular Sciences, University College London.

Prof Hausenloy conducts both basic, translational and clinical research in the areas of ischaemic heart disease, heart failure, cardioprotection, and cardiac magnetic resonance imaging (MRI). His main research focus is on discovering novel therapies for protecting the heart against the detrimental effects of acute ischaemia/reperfusion injury (IRI) in order to prevent the onset of heart failure. He uses a translational approach to cardioprotection ranging from cellular and animal models of acute IRI to proof-of-concept clinical studies in acute myocardial infarction and cardiac bypass surgery patients, and finally to large multi-centre randomised clinical trials focused on clinical outcomes. He is also interested in both small animal and clinical cardiac positron emission tomography (PET) and MRI imaging in the context of acute myocardial infarction and cardioprotection, and more recently, has developed an interest in using human iPSC-derived cardiomyocytes to model cardiomyopathies in order to elucidate underlying mechanism and identify novel therapeutic targets. He has been principal investigator (PI) on over 30 research grants, and has authored 292 papers citations, and his H-index is 88. In 2018, he was named Highly Cited Researcher by Clarivate Analytics.

Education

  • PhD, University College London, UK, 2004
  • MBChB (Honours), University of Manchester, 1996
  • BSc Biomedical Sciences (First Class Honours), 1993

Professional Appointments and Committee Memberships

  • Heart Protection Theme Lead, National Heart Research Institute Singapore
  • Professor, Programme in Cardiovascular & Metabolic Disorders, Duke-NUS Medical School  
  • Senior Consultant, Department of Cardiology, National Heart Centre Singapore
  • Professor of Cardiovascular Medicine, University College London, UK 
  • Chair of EU-CARDIOPROTECTION CA16225 COST Action, October 2017 to Present
  • Member of the ESC Council on Basic Cardiovascular Science, September 2012 to Present
  • Fellow of the Royal College of Physicians (FRCP), October 2911
  • Fellow of the European Society of Cardiology (FESC), May 2009
  • Fellow of the American College of Cardiology (FACC), February 2009

Awards

  • Dean's Excellence Award in Research 2019, Duke-NUS, Singapore, February 2020
  • Doctor Honoris Causa, Semmelweis University, Budapest, Hungary, November 2019
  • Highly Cited Researcher 2018 (awarded to top 1% of researchers), November 2018
  • Fellow of the International Society of Heart Research (FISHR), September 2018
  • European Society of Cardiology (ESC) Outstanding Achievement Award, July 2013
  • Winner of the BSCR Marshall Research Excellence Award, July 2012
  • Fellow of the Royal College of Physicians (FRCP), October 2011
  • May 2009 Fellow of the European Society of Cardiology (FESC), May 2009
  • Fellow of the American College of Cardiology (FACC), February 2009
  • Winner of the Novartis Bursary, Novartis Mitochondrial Symposium, London, UK, November 2006
  • Finalist in Young Investigator Award, ISHR European Section meeting, Manchester, UK, June 2006
  • Winner of Young Investigator Award, British Cardiac Society, Glasgow, UK, May 2006
  • Winner of ISHR-Servier Research Fellowship, April 2006

Research Interests

  • Cardioprotection from acute myocardial infarction and heart failure (basic to clinical)
  • Human IPSC derived cardiomyocytes for modelling cardiac disease
  • Nanocarriers to deliver therapeutics to the heart
  • Cardiac MRI in acute myocardial infarction and heart failure

Publications

  • ​Remote Ischemic Preconditioning and Outcomes in Cardiac Bypass Surgery. Hausenloy DJ, Candilio L, Evans R, Ariti C, Jenkins DP, Kolvekar S, Knight R, Kunst G, Laing C, Nicholas J, Pepper J, Robertson N, Xenou X, Clayton T, Yellon DM. N Engl J Med 2015 Oct 8;373(15):1408-17. IF 70.67.
  • Quantifying the Area at Risk in Reperfused ST-Segment-Elevation Myocardial Infarction Patients Using Hybrid Cardiac Positron Emission Tomography-Magnetic Resonance Imaging. Bulluck H, White SK, Fröhlich GM, Casson SG, O'Meara C, Newton A, Nicholas J, Weale P, Wan SM, Sirker A, Moon JC, Yellon DM, Groves A, Menezes L, Hausenloy DJ. Circ Cardiovasc Imaging. 2016 Mar;9(3):e003900. doi: 10.1161/CIRCIMAGING.115.003900. IF 5.813.
  • Index of Microvascular Resistance and Microvascular Obstruction in Patients With Acute Myocardial Infarction. Bulluck H, Foin N, Carbrera-Fuentes HA, Yeo KK, Wong AS, Fam JM, Wong PE, Tan JW, Low AF, Hausenloy DJ. J Am Coll Cardiol Cardiovasc Interv. 2016 Oct 24;9(20):2172-2174. doi: 10.1016/j.jcin.2016.08.018. IF 9.544.
  • Residual Myocardial Iron Following Intramyocardial Hemorrhage During the Convalescent Phase of Reperfused ST-Segment-Elevation Myocardial Infarction and Adverse Left Ventricular Remodeling. Bulluck H, Rosmini S, Abdel-Gadir A, White SK, Bhuva AN, Treibel TA, Fontana M, Ramlall M, Hamarneh A, Sirker A, Herrey AS, Manisty C, Yellon DM, Kellman P, Moon JC, Hausenloy DJ. Circ Cardiovasc Imaging. 2016 Oct;9(10). pii: e004940. IF 5.813.
  • Importance of Sex-Specific Regression Models to Estimate Synthetic Hematocrit and Extracellular Volume Fraction. Lim EH, Le TT, Bryant J, Chung YC, Su B, Gan J, Hausenloy DJ, Cook SA, Chin CWL. J Am Coll Cardiol Cardiovasc Imaging. 2018 Feb 9. pii: S1936-878X(17)31177-4. doi: 10.1016/j.jcmg.2017.11.035. IF 10.975. 
  • Impact of Cardioprotective Therapies on the Edema-Based Area at Risk by CMR in Reperfused STEMI. Bulluck H, Chan MHH, Paradies V, Bryant JA, Hernández-Reséndiz S, Cabrera-Fuentes HA, Watson TJ, Chan MY, Tan JW, Hausenloy DJ. J Am Coll Cardiol. 2018 Jun 19;71(24):2856-2858. IF 18.639.
  • Comparative Effectiveness of Magnetic Resonance Perfusion and Fractional Flow Reserve. Nagel, E, Greenwood J, McCann GP, Shah AJ, Hussain ST, Plein S, Bucciarelli-Ducci C, Paul M, Westwood MA, Marber M, Richter WS, Puntmann VO, Shwenke C, Schulz-Menger J, Das R, Hausenloy DJ, Steen H, Berry C. N Engl J Med 2019 June 6. IF 70.67.
  • Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation. Mei Q, Bansal A, Jayakumar MKG, Zhang Z, Zhang J, Huang H, Yu D, Ramachandra CJA, Hausenloy DJ, Soong TW, Zhang Y. Nat Commun. 2019 Sep 27;10(1):4416. doi: 10.1038/s41467-019-12374-4. IF 11.880.
  • Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial. Hausenloy DJ, Kharbanda RK, Møller UK, Ramlall M, Aarøe J, Butler R, Bulluck H, Clayton T, Dana A, Dodd M, Engstrom T, Evans R, Lassen JF, Christensen EF, Garcia-Ruiz JM, Gorog DA, Hjort J, Houghton RF, Ibanez B, Knight R, Lippert FK, Lønborg JT, Maeng M, Milasinovic D, More R, Nicholas JM, Jensen LO, Perkins A, Radovanovic N, Rakhit RD, Ravkilde J, Ryding AD, Schmidt MR, Riddervold IS, Sørensen HT, Stankovic G, Varma M, Webb I, Terkelsen CJ, Greenwood JP, Yellon DM, Bøtker HE; CONDI-2/ERIC-PPCI Investigators. Lancet. 2019 Oct 19;394(10207):1415-1424. doi: 10.1016/S0140-6736(19)32039-2. IF 59.102.
  • Effect of remote ischaemic conditioning on platelet reactivity and endogenous fibrinolysis in ST-elevation myocardial infarction- a substudy of the CONDI-2/ERIC-PPCI randomised controlled trial. Gorog DA, Farag M, Spinthakis N, Yellon DM, Bøtker HE, Kharbanda RK, Hausenloy DJ. Cardiovasc Res. 2020 Mar 12. pii: cvaa061. doi: 10.1093/cvr/cvaa061. [Epub ahead of print]. IF 7.014.

Research Trials

  • Platelet inhibition to target reperfusion injury (PITRI trial)
  • Electroacupuncture in CABG surgery (EA-CABG trial)