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Assoc Prof Seneviratne Chaminda Jayampath

Principal Investigator

National Dental Centre Singapore

Profile

Associate Professor Chaminda "Jaya" Seneviratne is a Clinician Scientist in Singapore and a leading expert in Molecular Oral Microbiology. His track record includes 75 publications in reputed international journals (h-index=29, i10-index=52, 2563 citations, Google scholar), 13 book chapters and an edited book "Microbial Biofilms: OMICS Biology, Antimicrobials and Clinical Implications" Taylor & Francis CRC Press, 2017. He has successfully secured over S$ 5.9 million in research grants from local and international funding agencies including Singapore National Medical Research Council (NMRC). His research team has received 20 prestigious awards from the International Association for Dental Research (IADR). A/Prof. Jaya was nominated for the Distinguish Scientist Award of the IADR Pharmacology/Therapeutics/Toxicology (PTT) group in 2017.

A/Prof. Jaya received his BDS (Hons) and MPhil in Periodontal Medicine from the University of Peradeniya, Sri Lanka. He obtained his PhD in Oral Microbiology at The University of Hong Kong (HKU) with the Outstanding Research Postgraduate Award. He completed an advanced Immunology course from HKU Pasteur Institute and Proteomics Bioinformatics course from the European Bioinformatics Institute (EBI), UK. He served as an Assistant Professor at HKU (2010-2013) and at National University of Singapore (2013-2018). A/Prof Jaya's research group has ongoing studies on oral microbiome-systemic links. His research group has developed various in vitro, ex vivo and in vivo biofilm models and small-molecules-based drug discovery platforms.

Education

Professional Appointments and Committee Memberships

Principal Investigator, Oral Health Academic Clinical Programme (ACP), National Dental Centre Singapore, SingHealth
Lead, Singapore Oral Microbiomics Initiative (SOMI), National Dental Research Institute Singapore (NDRIS)
Associate Professor, Duke NUS Graduate Medical School
Secretary, Asia-Pacific Region, International Association for Dental Research (IADR-APR)
Treasurer, Southeast Asian Division, International Association for Dental Research (IADR-SEA)
Editorial Board/Associate Editor, Critical Reviews in Microbiology

Awards

Research Interests

Oral microbiome-systemic link in clinical cohorts
Microbial biofilms; mechanism of drug resistance and anti-biofilm agents
Salivary diagnostics
Candida infections; molecular mechanisms and novel therapeutics

Publications

Microbial Biofilms: OMICS Biology, Antimicrobials and Clinical Implications, Taylor & Francis CRC Press, Published May 8, 2017.
K Ellepola,T Truong , Y Liu , Q Lin, T K Lim, Y M Lee, T Cao , H Koo, C J Seneviratne*. Multi-omics analyses reveal synergistic carbohydrate metabolism in Streptococcus mutans-Candida Albicans mixed-species biofilms. Infect Immun 2019;87(10):e00339-19.
Truong T, Zeng G, Lim TK, Cao T, Pang LM, Lee YM, Lin Q, Wang Y, Seneviratne CJ*. Proteomics analysis of Candida albicans dnm1 haploid mutant unraveled the association between mitochondrial fission and antifungal susceptibility. Proteomics. 2019:e1900240.
Balan P, Chong YS, Umashankar S, Swarup S, Loke WM, Lopez V, He HG, Seneviratne CJ*. Keystone species in pregnancy gingivitis: A snapshot of oral microbiome during pregnancy and postpartum period. Front Microbiol 2018;9:2360.
Balan P, He HG, Cao F, Wong ML, Chong YS, Lopez V, Soh SE, Seneviratne CJ. Oral health in pregnant Chinese women in Singapore: A call to go beyond the traditional clinical care. Healthcare (Basel). 2018;6(3).
Suriyanarayanan T, Qingsong L, Kwang LT, Mun LY, Seneviratne CJ*. Quantitative proteomics of strong and weak biofilm formers of Enterococcus faecalis reveals novel regulators of biofilm formation. Mol Cell Proteomics 2018;17(4):643-54.
Ellepola K, Liu Y, Cao T, Koo H, Seneviratne CJ*. Bacterial GtfB augments Candida albicans accumulation in cross-kingdom biofilms. J Dent Res 2017;96(10):1129-35.
Seneviratne CJ*, Suriyanarayanan T, Swarup S, Chia KHB, Nagarajan N, Zhang C. Transcriptomics analysis reveals putative genes involved in biofilm formation and biofilm-associated drug resistance of Enterococcus faecalis. J Endod 2017;43(6):949-55.
Truong T, Zeng G, Lin Q, Lim TK, Cao T, Chan FY, Wang Y, Seneviratne CJ*. Comparative ploidy proteomics of Candida albicans biofilms unraveled the role of AHP1 in the biofilm persistence against amphotericin B. Mol Cell Proteomics. 2016;15(11):3488-500.
Seneviratne CJ*, Wang Y, Jin L, Wong S, Herath TDK, Samaranayake LP. Unravelling the resistance in microbial biofilms: Has proteomics been helpful? Proteomics 2012; 12:651-65.