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Trametinib

Drug Class: Commonly Known As: Category:
Mekinist Cancer-related

Trametinib - Side Effects, Precautions, and Contraindications

What side effects can Trametinib cause?

Common side effects include:

  • Skin rash (acne-like) ​
    • Moisturize your skin daily.
    • Avoid too much exposure to the sun as it may make the rash worse. Use sunscreen and covered clothing if you need to be under the sun for a long period of time.
  • Diarrhea
    • Drink plenty of fluids to replace those lost (2 litres everyday).
    • Avoid oily or spicy food and milk or dairy products.
  • Nausea (especially when treated together with Dabrafenib)
    • Take small, frequent meals throughout the day.
  • Feeling tired and lack of energy
    • Do not drive or operate machinery when you feel tired.
  • Joint or muscle ache
    • Apply a warm compress to the area that aches.
  • Increased blood pressure
    • Monitor your blood pressure regularly and record it down. Inform your doctor if you notice an increasing trend.

Rare but serious side effects include:

  • Unusual swelling of the ankles or feet
  • Sudden onset of cough, chest pain or shortness of breath
  • Fever of 38°C and above, especially with chills, pain or difficulty in passing urine
  • Unusual bleeding, bruising or black sticky stools
  • Warmth, pain, redness or discoloration on the arm or leg
  • Change in eyesight or eye pain
  • Very bad headache or giddiness

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Trametinib, what precautions must I follow?

Inform your healthcare professional if:

  • You are allergic to this medication
  • You or your partner become pregnant or is planning for pregnancy
    • You should use effective birth control during and for 4 months after stopping Trametinib.
  • You are breastfeeding
    • Do not breastfeed during and for 4 months after stopping Trametinib.
  • You have any other medical conditions such as heart problems or diabetes
  • You plan to have surgery, dental procedure or any other medical procedures done 

What food or medicine must I avoid when I take Trametinib?

​Inform your healthcare professional if you are taking or intend to take any other medication, supplements, traditional medications or herbal remedies.

Trametinib - Additional Information

​You may refer to the following website if you need more information: https://www.macmillan.org.uk/

  • Updated on Monday, September 30, 2019
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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