Prilocaine/Lignocaine

Drug Class:	Commonly Known As:	Category:
Prilocaine Hydrochloride + Felypressin	Prilocaine/Lignocaine

Prilocaine/Lignocaine - Side Effects, Precautions, and Contraindications

What side effects can Prilocaine/Lignocaine cause?

Common side effects include:

Whitening or redness of the skin
Puffiness of the skin
Burning or itching on the site of application

These side effects may disappear during treatment. If any of the following effects persist or are severe, consult your doctor. Rare but serious side effects include:

Allergic reactions which include

Swollen face/eyes/lips/tongue
Difficulty in breathing
Itchy skin rashes over your whole body

Small red dots (petechiae) at the application site, especially in children with skin problems (e.g., atopic dermatitis or eczema).
Methaemoglobinemia

Bluish or greyish color of the lips, nails, skin
Abnormal heartbeat
Seizures
Severe dizziness, passing out
Severe headache
Shortness of breath
Feeling weak or tired

Slow heartbeat
Change in balance or speech
Ringing in ears
Anxiety, restless, excitable, low mood
Feeling lightheaded, confused, or having blurred vision

Before taking Prilocaine/Lignocaine , what precautions must I follow?

Inform your healthcare professional if you have:

Allergy to prilocaine, lignocaine/lidocaine, local anaesthetics, or any of the other ingredients of this medication
Dermatitis or any other skin problems
Severe liver conditions
Severe heart rhythm conditions
Glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Methaemoglobinaemia (a blood disorder that causes the skin, especially around lips and nails, to turn brownish or greyish)
Infection, skin rash or broken skin at, or near the area where you want to apply EMLA cream
Plans to become pregnant, are pregnant or breastfeeding

The skin on which EMLA cream is applied may stay numb for up to several hours after the cream is removed. For this reason, you should be careful to avoid accidental injury to the treated area, such as scratching, rubbing or exposure to extreme temperatures, until complete sensation returns.
Avoid getting EMLA cream in your eyes, nose, or mouth. If you get EMLA in your eyes, rinse them with plenty of water. If the medication is swallowed, call a doctor immediately.
Do not apply to ruptured eardrum, anus, or children’s genital areas.
Children should be closely observed during and after use of EMLA cream, as they are at greater risk than adults for serious side effects, such as methaemoglobinemia.

What food or medicine must I avoid when I take Prilocaine/Lignocaine ?

Inform your doctor if you are taking

Other medications, especially

Antiarrhythmic drugs for heart problems e.g., amiodarone
Other local anaesthetics
Cimetidine
Beta-blockers
Other drugs which may trigger methaemoglobin formation e.g., sulfonamides, nitrofurantoin, chloroquine, dapsone, phenytoin, phenobarbital