Isotretinoin (for Neuroblastoma)

Isotretinoin is recommended to be taken with food and is usually taken twice daily.

Swallow capsules whole with a full glass of water.

Other ways if you are unable to swallow whole capsule:

• Pierce the capsule with a large-gauge needle OR use a scissors to snip the tip off the capsule (if the capsule is too hard, you can put the capsule in a small amount of lukewarm water to soften the outer shell). Squeeze the contents ​onto food for immediate consumption. It is best to use food with high fat content (e.g. peanut butter, cheese, chicken noodle soup broth, pudding, or ice cream) to help absorb the medicine.
• Chew the capsule to empty the contents. Shell of capsule can then be swallowed or spit out.

If you forget a dose, take it as soon as you remember. If it is nearer to the time of the next dose, skip the missed dose. Do not take two doses at the same time.

Do not repeat dose if vomiting occurs after dose has been administered, wait until the next scheduled dose. Contact the pharmacist or doctor if you (or your child) repeatedly miss doses due to vomiting, even with the administration of anti-vomiting medicine.