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Drug Class: Commonly Known As: Category:
Sulphonylureas Apo-Glyburide, Glyburide Adult

Glibenclamide - What is it for

​Glibenclamide is used to manage diabetes. It helps the pancreas to release more insulin to bring your blood sugar levels down.

Glibenclamide - Side Effects, Precautions, and Contraindications

What side effects can Glibenclamide cause?

​​​This medication may cause low blood sugar (hypoglycemia). Symptoms of low blood sugar are weakness, dizziness, hunger, sweating, trembling, blurred vision, walking unsteadily or fast heartbeat.

If you experience any of these low blood sugar symptoms, do the following immediately:

  • Step 1: Check your blood sugar with a home blood sugar meter (glucometer) if available. If your blood sugar level is less than 4 mmol/L, take 15 grams of sugar such as: 
    • 3 glucose tablets or 
    • Half a glass of fruit juice or
    • 3 teaspoons of sugar, honey or syrup
  • Step 2:  You should feel better after  15 minutes. If you have a home blood sugar meter, you should check your blood sugar level again.
  • Step 3: If your blood sugar level is still less than 4 mmol/L or you still have symptoms of low blood sugar, you should take another 15 grams of sugar.

If your symptoms still do not get better, see a doctor or go to the hospital immediately.

See a doctor or go to the hospital immediately if your blood sugar level is always low and experience symptoms even after taking amounts of sugar (see instructions above for management of low blood sugar).

 You may also gain weight with Glibenclamide. You are encouraged to exercise regularly to prevent weight gain associated with this medication.

Before taking Glibenclamide , what precautions must I follow?

​Inform your doctor if

  •  you are allergic to this medication or any of the other ingredients of this medication
  •  you have a genetic condition called Glucose-6 Phosphate Dehydrogenase (G6PD) deficiency
  • you are pregnant, planning to become pregnant, or breastfeeding
  • you have a heart condition, kidney or liver problem
  • you drink alcohol often
  • you are eating less than usual due to sickness/ changed diet as your medication dosage may need to be changed
  • you are exercising more than usual or if you want to change your usual diet, as this may affect your blood sugar level.

 If your doctor has informed you that you need to do a fasting blood test, skip your medication until after you have your blood taken and are ready to eat.

What food or medicine must I avoid when I take Glibenclamide ?

​Avoid taking alcohol with this medication as it may cause symptoms such as flushing, nausea, vomiting, headache, fast heartbeat, fast breathing and giddiness.

Glibenclamide - Dosage and How to Use

How should Glibenclamide be used?

​​Take the tablet(s) as directed by your doctor immediately before meal(s). Do not miss or delay meals after taking the medication.

What should I do if I miss a dose?

​If you miss a dose, take your next dose immediately before your next meal and skip the dose you missed. Do not double your dose or use extra medication to make up for the missed dose.

What should I do if I overdose?

​If you take more than the recommended dose, please seek medical advice immediately.

Glibenclamide - Handling

How should I handle Glibenclamide safely?

Glibenclamide - Storage

How should I store Glibenclamide ?

;#Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#

How should I dispose of Glibenclamide safely?

​Pack this medicine into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.

Glibenclamide - Additional Information

  • Updated on 5/16/2019 12:00:00 AM
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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