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Acitretin

Drug Class: Commonly Known As: Category:
Neotigason

Acitretin - What is it for

​Acitretin is mainly used to treat severe psoriasis, an inflammatory condition of the skin with increased turnover of skin cells, creating red, scaly patches of skin. The medication works by regulating the normal growth and development of skin cells.

Acitretin - Side Effects, Precautions, and Contraindications

What side effects can Acitretin cause?

  • ​Red, cracked and sore lips
    • Apply lip balm frequently
  • Irritated and dry eyes
    • Apply lubricating eye-drops or artificial tears to prevent this. Stop the use of contact lenses if irritation persists.
  • Dry skin, sometimes with peeling
    • Apply moisturiser regularly to manage skin dryness
  • Dry mouth
    • Chew sugar-free gum, suck on sugar-free hard candies or ice chips, sip water regularly
  • Dry nose. Nose bleeding may occur for severe cases
    • Apply white soft paraffin to the lining inside of your nose
  • Muscle and joint pain or stiffness
    • Avoid intense physical exercise to prevent it from getting worse
  • Increased risk of sunburn
    • Avoid staying directly under sunlight for long period of time. Use a broad-spectrum sunscreen product with Sun Protection Factor (SPF) of at least 30 and wear protective clothing when you are exposed to direct sunlight.

Before taking Acitretin, what precautions must I follow?

​Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication
  • You are pregnant, planning to become pregnant, or breastfeeding:
    • This medication can cause serious harm to an unborn child. You are advised to practice strict birth control for at least 1 month before starting on the medication, when taking the medication and at least 3 years after stopping the medication.     
    • This medication may pass into breast milk and harm your baby. Do not breastfeed for at least 3 years after stopping the medication
  • You have diabetes, high cholesterol or triglycerides (fat in the blood), liver or kidney disease
  • You are planning to donate blood. Do not donate blood for at least 3 years after stopping the medication. This is to prevent passing donated blood to a pregnant woman and causing harm to the baby.
  • You are taking any other medications, including supplements, traditional medications and herbal remedies

What food or medicine must I avoid when I take Acitretin?

  • ​You should avoid taking alcohol when taking this medication and for 2 months after stopping it. Alcohol causes the medication to stay longer in the body and increases the risk of side-effects.
  • Do not take vitamin A supplements or multivitamins that contains vitamin A.
  • Do not take this medication if you are currently taking any Tetracycline class of antibiotics (such as Doxycycline, Minocycline, and Tetracycline).  This can increase the risk of high pressure in the head leading to headaches, nausea and vomiting.

Acitretin - Dosage and How to Use

How should Acitretin be used?

Acitretin should be taken with or after food for better absorption.  Swallow the capsule whole, do not crush or chew it.

What should I do if I miss a dose?

​If you forget to take a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose.

What should I do if I overdose?

Acitretin - Handling

How should I handle Acitretin safely?

Acitretin - Storage

How should I store Acitretin?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#

How should I dispose of Acitretin safely?

​Pack acitretin into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.

Acitretin - Additional Information

​The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

Some of these side effects include:

  • Liver problem: Signs include dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin
  • Low mood (depression)
  • Blurred vision or change in vision    
  • Severe headache
  • Nausea
  • Severe backache
  • Hair loss     

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

  • Updated on
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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